Background: Chronic liver disease (CLD) is a significant contributor to morbidity and mortality globally, exhibiting a diverse range of clinical symptoms and unpredictable results. For successful clinical management and prognostication, it is important to find out how bad the disease is and what factors might lead to bad outcomes early on. Methods: A cross-sectional study was conducted in a hospital setting involving 180 adult patients diagnosed with chronic liver disease. Data on demographics, etiological factors, clinical manifestations, laboratory parameters, and complications were collected. The severity of the disease was evaluated using the Child–Pugh classification and the Model for End-Stage Liver Disease (MELD) score.

Results: Most of the patients were middle-aged men, and the most common cause of their liver disease was drinking too much alcohol. Jaundice and ascites were the main signs and symptoms. The majority of patients exhibited moderate to severe illness, with 76.7% categorized as Child–Pugh Class B or C. Recurrent ascites and variceal hemorrhage were common sequelae, with an in-hospital death rate of 12.2%. A multivariate analysis found that a MELD score of 25 or higher, a serum albumin level of less than 2.5 g/dL, hepatic encephalopathy, and an increased INR were all independent risk factors for death.

Conclusion: Patients with chronic liver disease commonly present with advanced disease and significant complications. Prognostic scores and key laboratory parameters are valuable in identifying high-risk patients and guiding clinical decision-making.