Autoimmune diseases have chronic inflammation as the most prevalent symptom, which has a detrimental impact on one’s quality of life. This disease has both genetic and environmental factors contribute to the susceptibility to this condition. The release of a variety of inflammatory cytokines, cytotoxic and immune regulatory factors is responsible for the disease’s severity and progression. The objective of the study is to assess the role of yoga in healing autoimmune diseases. Data collection is in accordance with autoimmune disease, the samples were able to provide responses and exchange information. Total 50 depressed, anxious and stressed participants having autoimmune disease joined. The collected data was analyzed using statistical software SPSS version 22.0. Results depicted the percentage of participants in the severe stress category was 14% at the beginning, which reduced to 0% after 12 months of yoga intervention. Stress in severe category of participants were 14% and completely reduced to 0% in 12 months; 14% moderate participants were reduced to 2% after complete yoga treatment. Yoga facilitates the management of autoimmune conditions by fostering relaxation, reducing inflammation, and fostering overall health. Gentle poses, deep breathing, restorative yoga, mindfulness meditation, and personalized therapy are all effective methods for reducing tension and bolstering the immune system.