A challenge to enhancing live birth rates is the oxidative stress on oocytes retrieved from patients undergoing in vitro fertilization (IVF). The purpose of this research is to find out whether oxidant/antioxidant factors can predict oocyte count and quality. In the cumulus cells of patients that were continuing IVF treatment, the activities of CAT, GST, ARE enzymes, and malondialdehyde (MDA) levels were examined. Statistical analysis revealed that the high responders’ cumulus cell GST enzyme activity was significantly higher than that of the poor responders’ and normo responders’ groups. There was no statistically significant difference between the groups when looking at the activity of the cumulus cell CAT and ARE enzymes. The high responder group’s remarkable improvement in oocyte status and quality is likely due to the influence of oxidative stress, as shown by their markedly reduced MDA levels and markedly increased GST enzyme activity